Adelita D. Mendoza

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

The paper identifies a zinc-regulated genetic pathway in C. elegans that activates lysosome remodeling through HIZR-1 and HLH-30/TFEB to enhance zinc detoxification.

The paper shows that lysosomes in C. elegans expand to store zinc, copper, and manganese, with metal transporters localizing to both acidified and expansion compartments.

The paper identifies a single HZA enhancer that controls two head-to-head genes in C. elegans under metal stress, demonstrating enhancer function in regulating multiple genes.