Sadra Sadeh

Inferring state-dependent functional circuit motifs using higher-order interactions analysis

The paper introduces CHOIR, a method to analyze higher-order interactions in neuronal recordings, revealing circuit motifs associated with different brain states and activity patterns in mice.

Population activity of mossy fibre axon input to the cerebellar cortex during behaviours

The paper investigates the population activity of mossy fibre axons in the cerebellar cortex during different behavioural states, finding a high-dimensional, bidirectional code that supports sensorimotor associations.

Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

The paper shows that CA1 interneurons form a network promoting synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies.

A Biologically Inspired Attention Model for Neural Signal Analysis

This paper introduces SPARKS, a biologically inspired model that achieves high decoding accuracy and interpretability in neural signal analysis across multiple datasets.

Dynamic and selective engrams emerge with memory consolidation

The paper investigates how memory engrams evolve during consolidation, showing they become selective through inhibitory synaptic plasticity and dynamic composition changes.

Contribution of behavioural variability to representational drift

The paper shows that behavioural variability contributes to representational drift in mouse cortical areas, suggesting that drift can arise from changes in behavioural states rather than just stimulus-related factors.

Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation

This paper presents a computational model of hippocampal-thalamic-cortical circuits to study systems consolidation and engram dynamics, finding that coordinated synaptic plasticity across regions is essential for memory reorganization.

Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks

The paper investigates how excitatory-inhibitory balance affects neuronal assembly formation and dynamics in cortical networks, finding that different network regimes lead to distinct performance trade-offs in pattern completion and discrimination.

Theory of Neuronal Perturbome: Linking Connectivity to Coding via Perturbations

The paper models how single-neuron perturbations in mouse visual cortex relate to connectivity and coding, finding that specific excitatory-inhibitory connectivity explains feature-specific suppression.

Open Source Brain: a collaborative resource for visualizing, analyzing, simulating and developing standardized models of neurons and circuits

Open Source Brain provides a platform for visualizing, simulating, and collaboratively developing standardized neuronal and circuit models to improve model transparency and reproducibility.

Assessing the role of inhibition in stabilizing neocortical networks requires large-scale perturbation of the inhibitory population

The paper investigates how large-scale inhibition perturbations are needed to detect inhibition-stabilized networks in cortical models, suggesting new experimental approaches are required.