Thomas D. Mrsic‐Flogel

Zapit provides an open-source platform for random-access laser-scanning optogenetics in mice, enabling user-friendly and accessible experiments.

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

The paper shows that mice with ASD-related mutations exhibit similar computational and neural anomalies in prior updating during decision-making.

The paper identifies a thalamocortical disinhibitory circuit in mouse V1 that selectively amplifies unexpected visual stimuli, implementing sensory prediction errors through VIP and SOM interneuron interactions.

The paper shows that inhibitory neurons in mouse primary visual cortex selectively connect with excitatory neurons based on response similarity, stabilizing network dynamics and enabling subnetwork competition.

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.

The paper shows that learning realigns cortical network dynamics to better integrate relevant sensory input in mice, explained by changes in excitatory-inhibitory connectivity.

The paper adds different types of recurrence to a neural network and finds that bio-inspired recurrence improves classification of noisy images, while task-trained recurrence behaves differently.

This paper develops a standardized task for measuring decision-making in mice, showing reproducible results across multiple laboratories and providing a public dataset and tools.

The paper uses calcium imaging in mice to show that sensory evidence and temporal expectation interact to drive distinct cortical activity patterns during decision-making.

This study shows that mice's higher visual cortex neurons respond more strongly to a cursor when they control it compared to passive viewing, with increased response as the cursor approaches the target.

This study shows that cerebellar output neurons exhibit preparatory activity similar to motor neocortex, and silencing them suppresses neocortical preparatory signals.

This study shows that individual neurons in V1 and RSP cortex form distinct cortical network connections that change with locomotion state.

This study maps axonal projection patterns of 591 V1 neurons in mice, finding most neurons broadcast to multiple cortical targets rather than sending dedicated projections to single areas.

The paper investigates how large-scale inhibition perturbations are needed to detect inhibition-stabilized networks in cortical models, suggesting new experimental approaches are required.

The paper investigates how projection neurons in primary visual cortex connect locally and find that target specificity constrains local connectivity independently of response similarity.