Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity
Adrián Varela-Vázquez, Amanda Guitián‐Caamaño, Paula Carpintero-Fernández, Alexander Carneiro-Figueira, Vanesa Álvarez, Marta Varela-Eirín, Teresa Calleja-Chuclá, Susana B. Bravo, Anxo Vidal, Juan Sendón-Lago, Marina Rodríguez-Candela Mateos, José Ramón Caeiro, Victoria Sanz‐Moreno, Trond Aasen, Miguel G. Blanco, , María D. Mayán
This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.
Nature Communications · Jul 4, 2025Peer-reviewedCancer Biology