Dana M. Lapato

Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank

This study identifies prevalence and disease risks for male and female sex chromosome trisomies using registry data from 1.5 million participants, finding shared phenotypic associations across trisomy subtypes.

Oral Contraceptive Use Is Associated with Significant Differences in MicroRNA Cargo of L1CAM-Associated Extracellular Vesicles

The paper identifies 12 microRNAs with differential expression in L1CAM-associated extracellular vesicles linked to oral contraceptive use and links them to the Gonadotropin-releasing hormone receptor pathway.

The Splice Index as a prognostic biomarker of strength and function in myotonic dystrophy type 1

The paper introduces the Myotonic Dystrophy Splice Index (SI) as a biomarker that correlates with muscle strength and mobility in DM1 patients.

Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian Randomisation

This study uses twin-based Mendelian randomisation to find bidirectional causation between smoking and blood DNA methylation at multiple genomic sites.

Neuron Enriched Exosomal MicroRNA Expression Profiles as a Marker of Early Life Alcohol Consumption

The paper examines the relationship between early life alcohol consumption and neuron-enriched exosomal miRNA expression, finding significant associations with specific miRNAs and biological functions.

Maternal Biological Age Assessed in Early Pregnancy is Associated with Gestational Age at Birth

This study shows that maternal biological age estimated in early pregnancy predicts gestational age at birth, with effects mainly driven by self-identified African American participants.

Replicated Umbilical Cord Blood DNA Methylation Loci Associated with Gestational Age at Birth

This study identifies DNA methylation loci in umbilical cord blood associated with gestational age at birth and links them to inflammation and innate immunity pathways.

Predictive Validity of a DNA Methylation-Based Screening Panel for Postpartum Depression

The paper evaluates a DNA methylation-based screening test for postpartum depression, finding higher predictive validity in women with prior depression history than in the general cohort.

DNA Methylation Associated with Postpartum Depressive Symptoms Overlaps Findings from a Genome-wide Association Meta-Analysis of Depression

The paper identifies DNA methylation regions associated with postpartum depressive symptoms and finds overlap with genome-wide association study results for depression.

Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental Genes

This study identifies DNA methylation changes in monozygotic twins linked to early-onset major depression, highlighting neurodevelopmental gene involvement.