John M. Hettema

Gene-drug interactions identify genomic loci that enhance statin effectiveness in lowering LDL cholesterol.

The paper identifies gene-statin interactions that enhance statin effectiveness in lowering LDL cholesterol using genome-wide analyses in the UK Biobank and All of Us.

Genome-wide analyses of quantitative generalised anxiety symptom severity

This study conducts a genome-wide association analysis of generalised anxiety symptom severity, identifying 80 significant variants and showing genetic correlations with other mental and physical health traits.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

A major role for common genetic variation in anxiety disorders

This study identifies five novel genome-wide significant loci for anxiety disorders and finds significant genetic correlations with depression, insomnia, and coronary artery disease.

Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental Genes

This study identifies DNA methylation changes in monozygotic twins linked to early-onset major depression, highlighting neurodevelopmental gene involvement.