Julien Bobe

miR-202 drives medaka fertility by targeting antagonistic Yap-dependent transcriptional regulators tead3b and vgll4b in a sex-dependent manner

This study shows miR-202-5p regulates medaka fertility by targeting tead3b and vgll4b in a sex-dependent manner, leading to specific reproductive defects in males and females.

Identification of miR-187 as a modulator of early oogenesis and female fecundity in medaka

This paper identifies miR-187 as a regulator of early oogenesis and female fecundity in medaka through CRISPR/Cas9 knockout and transcriptomic analysis.

Circulating microRNAs reveal egg-brain crosstalk and a brain-specific microRNA linked to the onset of the next reproductive cycle in iteroparous salmonids

The paper identifies miR-139-5p as a brain-specific microRNA linked to the onset of the next reproductive cycle in iteroparous salmonids through changes in circulating miRNA levels following egg removal.

Salmonids reveal principles of regulatory evolution following autotetraploidization

The paper studies gene regulatory evolution in salmonids after autotetraploidization, finding that it is influenced by developmental and tissue-specific factors, with constraints at advanced embryogenesis.

Identifying sexually dimorphic circulating microRNAs in gonochoristic and hermaphroditic marine fish species.

The paper identifies sex-specific circulating microRNAs in marine fish species to distinguish males from females and track sexual development stages.

Identification of sex-biased miRNA markers informative of heat-past events

The paper identifies sex-biased miRNA markers that reflect past thermal events in European sea bass gonads, with some markers showing conserved sex-skewed expression across multiple fish species.

Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes

The paper examines gene expression variability across organs in three ray-finned fish species, finding that brain-biased genes show stable regulation despite inter-individual differences.

Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production

The paper identifies a miRNA phenotypic target through de novo analysis in a medaka model, revealing miR-202 regulation of egg production via the Hippo pathway.

Genomic disruption of type II vitellogenin leads to vitellin membrane deficiencies andsignificant mortalities at early stages of embryonic development in zebrafish (Danio rerio)

This study uses CRISPR/Cas9 to disrupt vtg2 in zebrafish, revealing its essential role in vitellin membrane formation and early embryonic survival.

Deciphering sex-specific miRNAs as heat-recorders in zebrafish

The paper identifies sex-specific miRNAs in zebrafish gonads that respond to heat treatment, suggesting their potential as epigenetic markers for environmental exposure.

An ancient truncated duplication of the anti-Mullerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family

The paper identifies a truncated duplication of the amhr2 gene on the Y chromosome in Pangasiid catfishes as a conserved master sex-determining gene.

A non-functional copy of the salmonid sex determining gene (sdY) is responsible for the "apparent" XY females in Chinook salmon, Oncorhynchus tshawytscha.

The study identifies a non-functional sdY gene variant in XY Chinook salmon females that disrupts testicular differentiation by impairing estrogen synthesis.

Neurodevelopment vs. the immune system: complementary contributions of maternally-inherited gene transcripts and proteins to successful egg development in fish

This study investigates the distinct roles of maternally-inherited mRNAs and proteins in fish egg development, showing they contribute to neurodevelopment and immune protection respectively.

Circulating miRNA diversity, origin and response to changing metabolic and reproductive states, new insights from the rainbow trout

The paper identifies circulating miRNAs as biomarkers of metabolic and reproductive states in rainbow trout using small RNA-seq and qPCR, showing fluid-specific miRNAomes and candidate biomarkers for myogenesis and reproductive success.

C-Eci: A Cubic-Eci Combined Clearing Method For 3D Follicular Content Analysis In The Fish Ovary

The paper introduces a 3D imaging method for fish ovary analysis, addressing high lipid content challenges through a combined clearing technique.

VisEgg: A robust phenotyping tool to assess rainbow trout egg features and viability

VisEgg quantifies rainbow trout egg viability by analyzing hydration-induced whitening, correlating with hatching rates and distinguishing viability from other fertilization failures.

Genome editing reveals reproductive and developmental dependencies on specific types of vitellogenin in zebrafish (Danio rerio)

This study uses CRISPR/Cas9 to knockout specific vitellogenin genes in zebrafish, revealing their essential roles in reproduction and development and uncovering genetic compensation mechanisms.

MicroRNA-202 (miR-202) controls female fecundity by regulating medaka oogenesis

This study shows that miR-202 is critical for female fecundity in medaka, as its knockout leads to reduced egg production and fertility.

foxr1 is a novel maternal-effect gene in fish that regulates embryonic cell growth via p21 and rictor

The foxr1 gene in zebrafish is a novel maternal-effect gene required for proper cell division in early embryonic development through regulation of p21 and rictor.

Lost in translation: egg transcriptome reveals molecular signature to predict developmental success and novel maternal-effect genes

The paper identifies gene signatures in zebrafish eggs that predict developmental success and discovers two new maternal-effect genes involved in vertebrate reproduction.