Tibor van Welsem

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

This study shows that DOT1L influences dendritic cell subset development and antigen presentation by modulating histone H3K79 methylation.

Recruitment of Fpt1 to tRNA genes requires TFIIIB and the N-terminal TPR array of TFIIIC subunit {tau}131

The paper investigates how Fpt1 is recruited to tRNA genes in budding yeast, revealing a dual role of TFIIIB and TFIIIC in its binding under different RNAPIII conditions.

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

A chromatin-associated regulator of RNA Polymerase III assembly at tRNA genes revealed by locus-specific proteomics

The paper identifies Fpt1 as a chromatin-associated regulator that promotes RNA Polymerase III eviction from tRNA genes in response to nutrient changes in yeast.

Decoding the chromatin proteome of a single genomic locus by DNA sequencing

The paper introduces Epi-Decoder, a DNA sequencing-based method to systematically identify and quantify the chromatin proteome of a specific genomic locus in budding yeast, revealing dynamic changes under replication stress.