Author

Rianne G. Bouma

Amsterdam University Medical CentersORCID 0000-0002-6652-1891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alsya J. AffandiiD· 2 shared Joeke G. C. Stolwijk· 2 shared Joke M. M. den HaaniD· 2 shared Negisa Seyed ToutounchiiD· 2 shared Veronique A. L. KonijniD· 2 shared Alexander FishiD· 1 shared Angeliki MoutsiopoulouiD· 1 shared Anne MensinkiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Alsya J. AffandiORCID

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2 papers

Recent·Most cited

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

Rianne G. Bouma, Willem-Jan de Leeuw, Aru Z. Wang, Muddassir Malik, Joeke G. C. Stolwijk, Veronique A. L. Konijn, Anne Mensink, Natalie Proost, Maarten K. Nijen Twilhaar, Tibor van Welsem, Negisa Seyed Toutounchi, Alsya J. Affandi, Jip T. van Dinter, Fred van Leeuwen, Joke M. M. den Haan

This study shows that DOT1L influences dendritic cell subset development and antigen presentation by modulating histone H3K79 methylation.

Life Science Alliance · Mar 18, 2026Peer-reviewedCell Biology

Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells

Hendrik J. Brink, Alsya J. Affandi, Sandra Man-Bovenkerk, N.C.C.T. Dekker, E.A. Große Wichtrup, Rianne G. Bouma, Negisa Seyed Toutounchi, Veronique A. L. Konijn, Joeke G. C. Stolwijk, John L. van Hamme, Katarzyna Olesek, D.A.M. Heijnen, Alexander Fish, Angeliki Moutsiopoulou, Patrick H. N. Celie, , Joke M. M. den Haan

The paper identifies VHH/single-domain antibodies that either block or enhance Siglec-1 ligand binding to sialylated pathogens on dendritic cells.

bioRxiv · Dec 22, 2025 · PreprintImmunology