This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.

DOI 10.1101/2025.01.15.633097

humanproteomics

𝕏 PostBluesky

GenomicsNature CommunicationsPeer-reviewedNov 16, 2023

Transcriptional Responses of Cancer Cells to Heat Shock-Inducing Stimuli Involve Amplification of Robust HSF1 Binding

Sayantani Ghosh Dastidar, Bony De Kumar, Bo Lauckner…·Sergei Nechaev

The paper investigates how HSF1 binding patterns remain consistent across different heat shock stimuli in cancer cells and links these patterns to transcription outcomes and chromatin accessibility changes.

16 citations

humanChIP-seq

𝕏 PostBluesky

GenomicsMolecular OncologyPeer-reviewedJul 10, 2021

Genomic analyses of high-grade neuroendocrine gynecological malignancies reveal a unique mutational landscape and therapeutic vulnerabilities

Haider Mahdi, Amy S Joehlin-Price, Esther Elishaev…·Ata Abbas

14 citations

humanwhole-exome sequencing

𝕏 PostBluesky

GeneticsHuman Molecular GeneticsPeer-reviewedJul 1, 2021

Redefining the PTEN Promoter: Identification of Two Upstream Transcription Start Regions

Dennis J. Grencewicz, Todd Romigh, Stetson Thacker…·Charis Eng

The paper identifies two new transcription start regions (TSRs) upstream of the PTEN promoter, expanding its regulatory landscape and suggesting potential clinical implications for PTEN-related disorders.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky