Author

Dennis J. Grencewicz

The Ohio State UniversityORCID 0000-0002-6322-2853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Daniel J. SpakowicziD· 3 shared Rebecca HoydiD· 3 shared Ahmad A. TarhiniiD· 2 shared Carlos H.F. ChaniD· 2 shared Charis EngiD· 2 shared Cornelia M. UlrichiD· 2 shared Jiangjiang ZhuiD· 2 shared Martin D. McCarteriD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Daniel J. SpakowiczORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Breast tumor microbiome regulates anti-tumor immunity and T cell-associated metabolites

Chin-Chih Liu, Dennis J. Grencewicz, Karthik Chakravarthy, Lin Li, Ruth Liepold, Matthew R. Wolf, Lynn M. Marcho, Naseer Sangwan, Alice Tzeng, Rebecca Hoyd, Sachin R. Jhawar, Stephen R. Grobmyer, Zahraa Al‐Hilli, Andrew P. Sciallis, Daniel J. Spakowicz, , Charis Eng

This study investigates how the breast tumor microbiome interacts with CD8+ TILs and metabolites, showing that Staphylococcus influences anti-tumor immunity and T cell-associated metabolites.

Scientific Reports · Apr 16, 2026Peer-reviewedCancer Biology

Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

Ning Yi Jin, Rebecca Hoyd, Ayse S. Yilmaz, Jiangjiang Zhu, YunZhou Liu, Malvenderjit S. Jagjit Singh, Dennis J. Grencewicz, Xiaokui Molly Mo, Matthew F. Kalady, Daniel W. Rosenberg, Caroline E Dravillas, Eric A. Singer, John David Carpten, Carlos H.F. Chan, Michelle L. Churchman, , Daniel J. Spakowicz

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

Cancer Research Communications · Oct 24, 2025Peer-reviewedCancer Biology

Candida albicans infiltrates colon and rectal cancers causing therapeutic resistance and decreased survival

Dennis J. Grencewicz, Alexander Loncar, Sylvain Ferrandon, McKenzie Kreamer, Dipankor Chatterjee, Yogita Mehra, Aspen Carson, Rebecca Hoyd, Shiva Jahanbakhshi, Fouad Choueiry, Matthew Z. Anderson, Martin Benej, Dustin E. Bosch, Jiangjiang Zhu, Jinghai Wu, , Daniel J. Spakowicz

This study identifies Candida albicans colonization in colorectal tumors as a factor linked to reduced survival and impaired radiation response.

bioRxiv · Sep 19, 2025 · PreprintCancer Biology

Redefining the PTEN Promoter: Identification of Two Upstream Transcription Start Regions

Dennis J. Grencewicz, Todd Romigh, Stetson Thacker, Ata Abbas, Ritika Jaini, Donal S. Luse, Charis Eng

The paper identifies two new transcription start regions (TSRs) upstream of the PTEN promoter, expanding its regulatory landscape and suggesting potential clinical implications for PTEN-related disorders.

Human Molecular Genetics · Jul 1, 2021Peer-reviewedGenetics