Joshua Cantlon-Bruce

The paper introduces nanoSPINS, a platform for high-throughput single-cell multiomics that integrates transcriptomic and proteomic profiling from the same cells, demonstrating improved throughput and statistical power.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

The paper introduces nanoSPLITS, a platform for simultaneous transcriptome and proteome profiling of single cells, and demonstrates its application in cell cycle regulation and cell type identification.

The paper introduces nPOP, a method for preparing single-cell samples for multiplexed proteomics, achieving accurate quantification of thousands of proteins per cell.

The paper introduces nPOP, a method for single-cell protein covariation analysis, revealing cell cycle dynamics and functional differences between melanoma subpopulations.

This paper introduces a nested nanowell chip to improve single-cell proteomics throughput and robustness, demonstrating the ability to quantify ~1500 proteins from ~100 cells with low abundance variation.