Fraser P. McCready

This study shows that SHANK2 variants cause hypersynchronous neuronal network activity in human iPSC-derived neurons, which is rescued by mGluR5 agonism.

The paper shows that disease-linked shank2 mutations alter condensate physical properties and composition, leading to aberrant RNA translation.

This study identifies hyperexcitable network events called reverberating super bursts in MECP2 null neuronal networks and shows they can be mitigated by a calcium chelator.

This study differentiates human hindbrain neuroepithelial stem cells into cerebellar granule neurons in vitro, recapitulating key progenitor states and showing SHH's role in lineage specification and maturation.