Author

Fu Gui

Brigham and Women's HospitalORCID 0000-0001-8329-7118Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Adam Stuart KibeliD· 1 shared Anne FassliD· 1 shared Baishan JiangiD· 1 shared Celine Pana· 1 shared Gary Andrew BradshawiD· 1 shared Jens W. KöllermanniD· 1 shared Jia LiiD· 1 shared Jie JiangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adam Stuart KibelORCID

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1 paper

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedApr 23, 2025

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

Fu Gui, Baishan Jiang, Jie Jiang…·Jia Li

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

21 citationstop 2%

humanexperimental assay

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