Virgínea Farias

This study identifies STAT3 as a key driver of resistance to spindle inhibitors in glioblastoma, showing that therapy-induced senescence contributes to drug resistance by promoting quiescence and secreting factors that induce quiescence in proliferating cells.

This paper develops a mathematical model of GBM tumor growth and evaluates BMP4 as a differentiation therapy through virtual clinical trials, finding that continuous BMP4 delivery during radiotherapy is more effective than a single dose.