Author

Natanael Zarco

Mayo ClinicORCID 0000-0002-1827-2667Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Ashley N. Haddock· 3 shared Athanassios Dovas· 3 shared Naveen K H Nagaiah· 3 shared Peter CanolliD· 3 shared Rajappa S. Kenchappa· 3 shared Steven S. RosenfeldiD· 3 shared Christian T. MeyeriD· 2 shared Courtney A. MilleriD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Ashley N. Haddock

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microtubule Acetylation Regulates the Malignant Phenotype of Glioblastoma and is a Promising Therapeutic Target

Natanael Zarco, Athanassios Dovas, Santanu Bhattacharya, Tanmay Kulkarni, Misha Amini, Yi Liu, Ashley N. Haddock, Naveen K H Nagaiah, Debrabrata Mukhopadhyay, Paola Suárez-Meade, Alfredo Quiñones‐Hinojosa, Courtney A. Miller, Theodore M. Kamenecka, Peter Canoll, Rajappa S. Kenchappa, Steven S. Rosenfeld

This study identifies ATAT1 as a therapeutic target in glioblastoma by showing its role in promoting tumor invasion, proliferation, and resistance, with potential for combination therapies.

bioRxiv · Jun 19, 2026 · PreprintCancer Biology

MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma

Rajappa S. Kenchappa, László Radnai, Erica J. Young, Natanael Zarco, Li Lin, Athanassios Dovas, Christian T. Meyer, Ashley N. Haddock, Alice Hall, Katalin Tóth, Peter Canoll, Naveen K H Nagaiah, Gavin Rumbaugh, Michael D. Cameron, Theodore M. Kamenecka, , Steven S. Rosenfeld

Cell · Jun 10, 2025Peer-reviewedCancer Biology

Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

Natanael Zarco, Athanassios Dovas, Virgínea Farias, Naveen K H Nagaiah, Ashley N. Haddock, Peter A. Sims, Dolores Hambardzumyan, Christian T. Meyer, Peter Canoll, Steven S. Rosenfeld, Rajappa S. Kenchappa

This study identifies STAT3 as a key driver of resistance to spindle inhibitors in glioblastoma, showing that therapy-induced senescence contributes to drug resistance by promoting quiescence and secreting factors that induce quiescence in proliferating cells.

iScience · Nov 4, 2024Peer-reviewedCancer Biology