Loizos Michaelides

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

This paper develops a mathematical model of GBM tumor growth and evaluates BMP4 as a differentiation therapy through virtual clinical trials, finding that continuous BMP4 delivery during radiotherapy is more effective than a single dose.