Davood Norouzi

This paper introduces a novel genome engineering method for iPSCs that enables efficient multiplex gene editing and clone selection, improving the precision and speed of iPSC-based therapies.

This paper introduces L-PGI, a ligase-mediated gene editing system that enables efficient and precise genomic integration in both dividing and nondividing cells, overcoming limitations of reverse transcriptase-based methods.

The paper proposes a three-layer loop-extrusion model to explain mitotic chromosome folding, showing it can reproduce structural features observed in Hi-C maps and microscopy.

The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.

The paper uses multi-contact 3C data to show that chromosomes and compartment domains in the human genome are largely unentangled.

The paper uses simulations to show two distinct topoisomers of the 30-nm chromatin fiber with different DNA linking numbers, suggesting topological polymorphism may affect transcription.

The paper experimentally tests predictions about DNA topology in nucleosome arrays, showing linker length affects DNA linking number and topological structure.