Michael D. Solga

Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours

This study examines the 24-hour excretion patterns of urinary extracellular vesicles (uEVs) and their cargo in healthy subjects, revealing temporal variations and associations with urine parameters.

Methanogenic archaea bolster mucosal homeostasis and protect from colitis

This study shows that methanogenic archaea enhance intestinal epithelial regeneration, mucus production, and regulatory T cell accumulation, protecting against colitis.

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J mice

This study identifies SM/J mice as a model for spontaneous disc herniations and shows neuroimmune changes drive chronic discogenic pain.

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

High-dimensional spectral flow cytometry of activation and phagocytosis by peripheral human polymorphonuclear leukocytes

The paper introduces a 22-color spectral flow cytometry panel to profile human PMNs for activation, degranulation, phagocytosis, and other responses using phorbol ester and bacterial challenges.

Novel wheat germ agglutinin-based mass cytometry cell barcoding reagent for heterogeneous, live or fixed sample

This paper develops a wheat germ agglutinin-based barcode for mass cytometry that works on both live and fixed cells, showing stable yields and no differential performance across PBMC lineages.