Author

Madison E. McCanna

The Wistar Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:plant (other)· 1 Research Focus:protein design· 1

Frequent Co-Authors

Amber KimiD· 2 shared Colby J. AgostinoiD· 2 shared Daniel W. KulpiD· 2 shared Jesper PalleseniD· 2 shared Kelly Bayruns· 2 shared Zi Jie LiniD· 2 shared Alana Huynh· 1 shared Amelia EscolanoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Amber KimORCID

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Author profile →

2 papers

Recent·Most cited

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

Rumi Habib, Shahlo O. Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh, Colby J. Agostino, Nicholas J. Tursi, Kirsten J. Sowers, Jinwei Huang, Ryan S. Roark, Mansi Purwar, Younghoon Park, Kasirajan Ayyanathan, Hui Li, , Daniel W. Kulp

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedImmunology

Machine learning enables de novo multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

Andrew Nelson, Samuel E. Garfinkle, Zi Jie Lin, Joyce H. Park, Amber Kim, Kelly Bayruns, Madison E. McCanna, Kylie M. Konrath, Colby J. Agostino, Daniel W. Kulp, Audrey R. Odom John, Jesper Pallesen

The paper designs a multi-epitope immunogen for malaria using machine learning, demonstrating its ability to bind and orient three copies of the L9 antibody.

Proceedings of the National Academy of Sciences · Dec 3, 2025Peer-reviewedBiophysics