Yonghao Yu

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

This study identifies PARP1 trapping as the key mechanism by which PARP inhibitors trigger innate immunity, while PARP1 degraders avoid this response.

This study identifies LARP1 as a major phosphorylation substrate of mTORC1 and elucidates its role in regulating TOP mRNA translation.