Jan Jacob Schuringa

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

This paper introduces a bioinformatics framework for automated cell type annotation and patient stratification using CyTOF data, showing improved sensitivity and specificity and predictive survival analysis in leukemia.