Author

Ayşegül Erdem

de Duve Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Fleur Leguay· 2 shared Nick van GasteliD· 2 shared Andrew A. LaneiD· 1 shared Azeem ShardaiD· 1 shared Charles VidoudeziD· 1 shared David T. ScaddeniD· 1 shared Didier VertommeniD· 1 shared Francesco CaligioreiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Fleur Leguay

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 3, 2026

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells

Nithya Balasundaram, Ayşegül Erdem, Azeem Sharda…·Nick van Gastel

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

DOI 10.64898/2026.03.02.708949

humanmetabolomics

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Cancer BiologyCancer & MetabolismPeer-reviewedMay 19, 2025

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival

Ayşegül Erdem, Séléna Kaye, Francesco Caligiore…·Nick van Gastel

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

24 citationstop 1%

humanproteomics

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