Larissa Frank

This study shows that myeloid differentiation in hematopoietic progenitors starts during S phase and is linked to chromatin changes and HOXA9 activity.

The paper uses holistic genetic barcoding to map the lineage tree of tissue macrophage development in mice from gastrulation to adulthood, revealing local macrophage colonies that persist into adult organs.

Polytope enables high-resolution spatial fate-mapping by generating unique color codes through epitope barcoding in vivo.

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.