Tomoki Nishioka

The paper integrates transcriptomic and proteomic data from mTOR-related epilepsy patients to identify impaired oxidative phosphorylation as a molecular hallmark.

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

The paper identifies a phosphorylation pathway initiated by NMDARs that regulates synaptic growth and learning through a cascade involving CaMKII, ARHGEF2, Rho-kinase, and SHANK3.

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.