Kozo Kaibuchi

This study identifies KCNQ2/3 potassium channels as regulators of synaptic remodeling during withdrawal, showing their activation can suppress cocaine-seeking behavior.

This study compares the effects of fasudil and KD025 on serotonin and dopamine release in the nucleus accumbens of mice, finding distinct roles for Rho-kinase 1 and 2 in neurotransmitter regulation.

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

The paper integrates transcriptomic and proteomic data from mTOR-related epilepsy patients to identify impaired oxidative phosphorylation as a molecular hallmark.

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

This study shows that psychosocial stress alters feeding behavior patterns in mice through disruptions in the mesolimbic dopamine system, suggesting these patterns could serve as biomarkers for stress and neuropsychiatric disorders.

The paper identifies a phosphorylation pathway initiated by NMDARs that regulates synaptic growth and learning through a cascade involving CaMKII, ARHGEF2, Rho-kinase, and SHANK3.

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.

This study shows that TTBK1 and Aβ synergistically induce CRMP2 phosphorylation, leading to neurite degeneration and pTau accumulation in AD mouse models.