Douglas P. Kiel

This study uses proteome-wide Mendelian randomization to identify 18 circulating proteins causally linked to bone mineral density and fracture risk, with TIMP2 showing strong associations with lower BMD and increased fracture risk.

This study identifies 33 genetic variants associated with trabecular bone score (TBS) and finds a potential causal link between TBS and fracture risk independent of bone mineral density.

The paper identifies shared molecular mechanisms between Alzheimer's Disease and Osteoporosis using transcriptomic network analysis across brain and bone tissues.

Over 400 million variants, 97% below 1% frequency, emerge from deep whole-genome sequencing of 53,831 diverse TOPMed participants; TOPMed haplotypes enable imputation down to ~0.01% frequency.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.

This paper uses machine learning to predict osteoporotic fracture risk from genotypes, finding that genomic predictions outperform clinical risk factors in identifying fracture risk.

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.