David J. Solecki

An Interpretable 3D Bag-Of-Visual-Words Pipeline for Volumetric Microscopy Classification

This paper introduces an interpretable 3D Bag-of-Visual-Words pipeline for volumetric microscopy classification, showing it can accurately classify and localize biologically relevant structures in complex datasets.

Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella.

This study shows that JAM-C on cerebellar granule neurons interacts with glial cells to recruit Pard3 and drebrin, enabling cell sorting and layer-specific positioning during cerebellar development.

Antagonistic action of Siah2 and Pard3/JamC to promote germinal zone exit of differentiated cerebellar granule neurons by modulating Ntn1 signaling via Dcc

The paper shows how Siah2 and Pard3/JamC modulate Ntn1 signaling via Dcc to control GZ exit of cerebellar granule neurons.

Siah2 integrates mitogenic and extracellular matrix signalslinking neuronal progenitor ciliogenesis with germinal zoneoccupancy.

This paper identifies Siah2 as a regulator linking Shh mitogenic signals and extracellular matrix cues to control cerebellar granule neuron progenitor ciliogenesis and germinal zone occupancy.

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma