Julia J. Winter

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

The paper uses CRISPR-based epigenetic editing to manipulate Cartpt expression in mice, showing it affects cocaine memory acquisition and extinction.

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.