Kyle S. Czarnecki

Neuron-specific epigenetic repression of Cdk5 impairs hippocampal-dependent memory in male and female mice

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

Hippocampal Cdk5 is regulated by distinct stress paradigms in male and female mice

The paper investigates sex-specific regulation of hippocampal Cdk5 in mice under different stress paradigms, finding male-specific changes in mRNA and protein levels under combined stress conditions.

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memory

The paper uses CRISPR-based epigenetic editing to manipulate Cartpt expression in mice, showing it affects cocaine memory acquisition and extinction.

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

Cell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse Striatum

The paper profiles cell-type specific histone post-translational modifications in mouse striatal neurons to uncover regulatory epigenomic features associated with neurobiological function and disease.