Shaun S. Sanders

The paper identifies S-acylation of GAPDH on cysteine 247 by ZDHHC5 and ZDHHC17 as essential for its association with axonal transport vesicles.

The paper develops a new S-acylation prediction tool, SAPPTree, by integrating sequence and structural features from experimentally confirmed sites to improve prediction accuracy.

The paper characterizes the expression, localization, and S-acylation of cytosolic deacylases in the brain and neurons, identifying their tissue and subcellular distribution.

This paper investigates ZDHHC13, a non-canonical S-acyltransferase, and finds it may function as a pseudoenzyme by facilitating S-acylation through interactions with other PATs.

The paper shows reduced S-acylation of SQSTM1/p62 in Huntington disease impairs autophagy by blocking autophagic flux and causing empty autophagosomes.

This study shows that palmitoylation of AnkG-190 stabilizes its localization in dendritic spines, and lithium reduces this modification, affecting its function and interaction with PSD-95.

This study investigates the role of HTT palmitoylation in Huntington disease by assessing its dysregulation in models and showing that modulating palmitoylation reduces mHTT toxicity.

This study identifies ZDHHC14 as a neuronal palmitoyl acyltransferase that regulates PSD93 and Kv1 channel clustering at the axon initial segment, affecting neuronal excitability.

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

This study identifies novel inhibitors of DLK palmitoylation using high-content screening, finding ketoconazole reduces DLK palmitoylation and c-Jun phosphorylation in neuronal models.