Author

Hirohisa Watanabe

Fujita Health UniversityORCID 0000-0001-8553-8536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Gen SobueiD· 2 shared Masahisa KatsunoiD· 2 shared Yuji TakahashiiD· 2 shared Akihiro YamanakaiD· 1 shared Akio KikuchiiD· 1 shared Akiyoshi KakitaiD· 1 shared Alessandro FillaiD· 1 shared Alexandra DürriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersNeuroscience

Gen SobueORCID

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4 papers

Recent·Most cited

Tegmental atrophy in isolated REM sleep behaviour disorder: Ex vivo-informed in vivo imaging

Munehiko Hirose, Kenji Yoshinaga, Yoshifumi Mori, Atsushi Shima, Nobukatsu Sawamoto, Noritaka Wakasugi, Hirohiko Imai, Masahiko Watanabe, Goichi Beck, Yuta Kajiyama, Ujiakira Nishiike, Hideki Mochizuki, Kazuya Kawabata, Keita Hiraga, Tomohiko Nakamura, , Japan-Parkinson’s Disease Progressive Markers Initiative (J-PPMI) cohort

This study identifies tegmental atrophy in iRBD using VBM and a novel brainstem atlas, linking atrophy in specific nuclei to autonomic dysfunction.

Brain Communications · Jan 1, 2026Peer-reviewedNeuroscience

Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer's Disease

Tomoharu Katayama, Hikaru Sugimoto, Keigo Morita, Hirohisa Watanabe, Shinya Kuroda

The paper integrates multi-omic data from Alzheimer's disease patients to reveal coordinated downregulation of energy-producing metabolic pathways.

bioRxiv · Sep 26, 2025 · PreprintSystems Biology

Stress-impaired reward pathway promotes distinct feeding behavior patterns

Yusuke Fujioka, Kaori Kawai, Kuniyuki Endo, Minaka Ishibashi, Nobuyuki Iwade, Dilina Tuerde, Kozo Kaibuchi, Takayuki Yamashita, Akihiro Yamanaka, Masahisa Katsuno, Hirohisa Watanabe, Shinsuke Ishigaki, Gen Sobue

This study shows that psychosocial stress alters feeding behavior patterns in mice through disruptions in the mesolimbic dopamine system, suggesting these patterns could serve as biomarkers for stress and neuropsychiatric disorders.

Frontiers in Neuroscience · May 9, 2024Peer-reviewedNeuroscience

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.

Yasuo Nakahara, Jun Mitsui, Hidetoshi Date, Kristine Joyce L. Porto, Yasuhiro Hayashi, Atsushi Yamashita, Yoshio Kusakabe, Takashi Matsukawa, Hiroyuki Ishiura, Tsutomu Yasuda, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yoshio Momose, Yuji Takahashi, , Shoji Tsuji

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

medRxiv · May 2, 2023 · PreprintGenetic & Genomic Medicine