Cécile Conrad

The Pentose Phosphate Pathway Regulates Myelo-Lymphoid Lineage Specification

This study identifies the pentose phosphate pathway's role in regulating myeloid versus lymphoid lineage specification in hematopoietic stem and progenitor cells through metabolic state-fate mapping.

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomes

The paper uses genetic barcoding and single-cell transcriptomics to identify evolutionary trajectories in breast cancer cells, linking them to poor patient survival.

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

The DivisionCounter, a method for counting large ranges of cell divisions in vivo, reveals cell dynamics of leukemic cell killing via CAR-T therapy

The paper introduces DivisionCounter, a method to count large cell divisions in vivo, showing leukemia tumor division rates are independent of microenvironment and CAR-T treatment.