Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

This study identifies an efficient split site for prime editors and demonstrates improved in vivo genome editing efficiency using dual-AAV delivery in mice.

The paper introduces STARRPeaker, a processing pipeline for STARR-seq data that improves enhancer detection by addressing sequencing biases and RNA stability effects.

The paper develops a custom ENCODE annotation for cancer genomics, highlighting TF-RBP interactions and network rewiring during oncogenesis, and validates findings using experimental assays.