Author

Zhike Lu

Westlake UniversityORCID 0000-0002-9238-7489Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Heng ZhangiD· 2 shared Lihong DingiD· 2 shared Lijia MaiD· 2 shared Binglin HuangiD· 1 shared Botao LiuiD· 1 shared Hui CheniD· 1 shared Jianbo LiiD· 1 shared Jiang DuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Heng ZhangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

Rong Zheng, Zhike Lu, Rongwei Wei, Young-Cheul Shin, Jiang Du, Qingfeng Zhang, Jianbo Li, Xiaoqi Wang, Yi Wei, Botao Liu, Yang Chen, Lihong Ding, Heng Zhang, Hui Chen, Jing Huang, Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

Nature Structural & Molecular Biology · Mar 18, 2026Peer-reviewedGenomics

Improved split prime editors enable efficient in vivo genome editing

Rong Wei, Zhenxing Yu, Lihong Ding, Zhike Lu, Keyi Yao, Heng Zhang, Binglin Huang, Miao He, Lijia Ma

This study identifies an efficient split site for prime editors and demonstrates improved in vivo genome editing efficiency using dual-AAV delivery in mice.

Cell Reports · Dec 31, 2024Peer-reviewedGenomics