Author

Lihong Ding

ORCID 0000-0003-2176-3616Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Heng ZhangiD· 2 shared Lijia MaiD· 2 shared Zhike LuiD· 2 shared Binglin HuangiD· 1 shared Botao LiuiD· 1 shared Hui CheniD· 1 shared Jianbo LiiD· 1 shared Jiang DuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenomics

Heng ZhangORCID

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2 papers

Recent·Most cited

GenomicsNature Structural & Molecular BiologyPeer-reviewedMar 18, 2026

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

Rong Zheng, Zhike Lu, Rongwei Wei…·Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

4 citationstop 2%

CRISPR screenexperimental assay

𝕏 PostBluesky

GenomicsCell ReportsPeer-reviewedDec 31, 2024

Improved split prime editors enable efficient in vivo genome editing

Rong Wei, Zhenxing Yu, Lihong Ding…·Lijia Ma

This study identifies an efficient split site for prime editors and demonstrates improved in vivo genome editing efficiency using dual-AAV delivery in mice.

19 citations

mouseexperimental assay

𝕏 PostBluesky