Claire Dugast‐Darzacq

This study uses PAPA-fSMT to investigate P-TEFb interactions and exchange in live cells, revealing dynamics of the 7SK ribonucleoprotein complex and its association with chromatin and BRD4.

The paper shows PAX3/7 transcription factors use distinct gene networks to spatially control spinal cell fates through repression and activation mechanisms.

The paper shows that RNA polymerase II depletion from the inactive X chromosome is due to reduced chromatin binding, not biophysical compartmentalization.

This study investigates how tuning low-complexity domain interactions in the oncogenic TF EWS/FLI1 affects transcription and oncogenic transformation in human cells.

The paper shows that herpesvirus creates replication compartments that recruit RNA Polymerase II through DNA interactions, not phase separation, leading to local protein accumulations.

The paper identifies an integrated gene repression mechanism in human cells through mRNA isoform toggling at the MDM2 locus, similar to yeast.

This study shows that RNA polymerase II CTDs undergo phase separation, forming clusters that are regulated by phosphorylation and CTD length.