Shasha Chong

This study uses single-molecule imaging to analyze dynamic EWS::FLI1 hubs in Ewing sarcoma cells, revealing their regulation and therapeutic targeting potential.

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

This study introduces PhaseID, a method to identify protein components in LLPS condensates formed by IDRs, revealing how LLPS tunes interaction selectivity and enables new cellular functions.

This study shows that optimal AR NTD multivalent interactions are required for enhancer assembly and transcriptional activity, with excessive condensation impairing function and potentially contributing to disease.

This study investigates how tuning low-complexity domain interactions in the oncogenic TF EWS/FLI1 affects transcription and oncogenic transformation in human cells.

This study uses live-cell single-molecule imaging to show that TF low-complexity domains form dynamic, selective interaction hubs that stabilize DNA binding and activate transcription.