Gloria Ann Brar

Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

This study identifies Gim3 as a critical regulator of meiotic chromosome segregation in budding yeast, revealing its role in spindle sensitivity to tubulin levels and meiotic cellular remodeling.

The UPR drives gametogenesis via an unexpected response, coordinating translation and ER structure

The paper shows that the endogenous UPR in budding yeast is essential for gametogenesis, coordinating translation and ER structure through a distinct mechanism from exogenous UPR activation.

Blm10 scaffolds 14-3-3 adaptors to the proteasome, and maintains cellular proteostatic balance and gamete quality

This study identifies Blm10 as a proteasome-associated protein that modulates proteasome activity and maintains proteostasis and gamete quality in yeast.

Glutamine codon-driven translational readthrough reveals context-dependent stop codon decoding fidelity

The paper shows that glutamine codon context and abundance influence stop codon readthrough in yeast, with a QXQ motif and global glutamine content affecting readthrough efficiency.

SPRINT-MS: A high-throughput platform for identifying protein-protein interactions using pooled IP-MS and sparse signal recovery.

SPRINT-MS identifies protein-protein interactions using pooled IP-MS and sparse signal recovery, achieving high throughput and efficiency comparable to individual IP-MS experiments.

A role for selective autophagy of the ER in gametogenic rejuvenation revealed by microfluidics-based lifespan profiling

The paper introduces a high-throughput microfluidic assay to study gametogenic rejuvenation in yeast and identifies Atg39 and Atg40 as molecular determinants of lifespan resetting.

UPR deficiency in budding yeast reveals a trade-off between ER folding capacity and maintenance of euploidy

This study shows that UPR deficiency in budding yeast leads to aneuploidy, revealing a trade-off between ER folding capacity and euploidy maintenance.

Truncated protein isoforms generate diversity of protein localization and function in yeast

The paper identifies 388 N-terminally truncated protein isoforms in yeast, showing they have distinct localization and functions compared to annotated proteins.

Dbp1 is a low performance paralog of RNA helicase Ded1 that drives impaired translation and heat stress response

This study shows Dbp1 is a less effective paralog of Ded1 in yeast, supporting impaired translation and lacking heat stress response, used in nutrient-deficient conditions.

Use of a ubiquitous gene-editing tool in budding yeast causes off-target repression of neighboring gene protein synthesis

The paper shows that deleting DBP1 in yeast using a selection cassette causes off-target repression of MRP51 through a LUTI-based mechanism, leading to mutant phenotypes.

Comprehensive analysis of meiosis-derived cDNA libraries reveals gene isoforms and mitochondrial proteins important for competitive fitness

The paper constructs and analyzes meiotic cDNA libraries in yeast to identify gene isoforms and mitochondrial proteins affecting competitive fitness and respiration.

Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster

The paper shows that transcriptional interference at the endogenous Adh locus in Drosophila melanogaster is developmentally regulated and tunable through distal promoter activity.

Evidence for an Integrated Gene Repression Mechanism based on mRNA Isoform Toggling in Human Cells

The paper identifies an integrated gene repression mechanism in human cells through mRNA isoform toggling at the MDM2 locus, similar to yeast.