Author

Guannan Zhou

Karolinska University HospitalORCID 0000-0001-9353-1908Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

André GörgensiD· 2 shared Doste Rashid MamandiD· 2 shared Oscar P. B. WiklanderiD· 2 shared Roosmarijn E. VandenbrouckeiD· 2 shared Samantha RoudiiD· 2 shared Samir EL AndaloussiiD· 2 shared Xiuming LiangiD· 2 shared Antje Maria ZickleriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

André GörgensORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles

Svetlana Pavlova, Doste Rashid Mamand, André Görgens, Antje Maria Zickler, Wenyi Zheng, Xiuming Liang, Oscar P. B. Wiklander, Manuchehr Abedi‐Valugerdi, Elien Van Wonterghem, Junhua Xie, Zheyu Niu, Samantha Roudi, Dongnan Yan, Ruhani Makkar, Guannan Zhou, , Samir EL Andaloussi

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

Journal of Extracellular Vesicles · Apr 1, 2026Peer-reviewedBioengineering

Efficient delivery of gene editors using intein-engineered virus-like particles

Guannan Zhou, Vincent Hou, Houze Zhou, Samantha Roudi, Juliette Suermondt, Oskar Gustafsson, Zheyu Niu, Doste Rashid Mamand, Lien Van Hoecke, Oscar P. B. Wiklander, Roosmarijn E. Vandenbroucke, Joel Z. Nordin, André Görgens, Samir EL Andaloussi, Xiuming Liang

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

bioRxiv · Jan 26, 2026 · PreprintMolecular Biology