Roosmarijn E. Vandenbroucke

Lemonite: identification of regulatory metabolites through data-driven, interpretable integration of transcriptomics and metabolomics data

Lemonite integrates transcriptomics and metabolomics data to identify regulatory metabolites acting on gene modules in glioblastoma and inflammatory bowel disease.

Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

Efficient delivery of gene editors using intein-engineered virus-like particles

This paper develops intein-engineered virus-like particles for efficient gene editing delivery, achieving robust gene editing in multiple cell types and organs.

Corelative light and electron microscopy (CLEM) image registration by blood vessel axes alignment

This paper introduces a method for aligning blood vessel axes in CLEM images to improve registration accuracy.

IL-34 empowers regulatory T cells with novel non-canonical function to safeguard brain barrier integrity during neuro-inflammation.

This study identifies IL-34 as a novel factor enabling regulatory T cells to maintain brain barrier integrity during neuro-inflammation, with implications for treating neurological disorders.

Newly discovered base barrier cells provide compartmentalization of choroid plexus, brain and CSF

The paper identifies a novel fibroblast subtype in the choroid plexus that forms a barrier between the choroid plexus stroma, brain, and cerebrospinal fluid.

Microfluidic interfaces for chronic bidirectional access to the brain.

This paper develops microfluidic interfaces for chronic fluid access to the brain in mice, enabling precise injection and long-term sampling of CSF and biomarkers.

Profiling of extracellular small RNAs highlights a strong bias towards non-vesicular secretion

The paper shows that most extracellular miRNAs are secreted non-vesicularly, with only <2% associated with EVs, even though EVs can stabilize miRNAs in serum.