Farren J. Isaacs

This study identifies GndA, a microprotein in Escherichia coli, which promotes cell growth during heat shock independently of its overlapping 6PGD protein.

The paper discovers and engineers an orthogonal translation system using metagenomic data to expand the genetic code with non-canonical amino acids.

The paper introduces Integrase-On-Demand (IOD), a method to identify integrases from bacteria and archaea that can integrate genetic cargo into target prokaryotes without requiring synthetic attB sites.

This study identifies and corrects fitness defects in genomically recoded E. coli, improving growth and functional capabilities.

The paper optimizes the production of a non-standard amino acid in E. coli by combining computational modeling and experimental validation of metabolic interventions.

This paper develops a hydrogel-based containment system for genetically modified microorganisms to enable safe, retrievable, and functional biosensing applications.

This paper optimizes eMAGE to achieve high-efficiency combinatorial genome editing in yeast with reduced spontaneous mutations and faster workflow.