Rachel E. Langston

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

This study compares two budding yeast disome systems, finding similar mechanisms of chromosome instability but conflicting results on chromosome size changes and higher instability frequency in the ChrV system.

This study shows that Cdc13 deficiency in budding yeast causes genome instability through replication-dependent telomere capping failure, leading to unstable chromosomes and rearrangements.