Both Genome Instability and Replicative Senescence Stem from the Shortest Telomere in Telomerase-Negative Cells
Prisca Berardi, Veronica Martinez-Fernandez, Anaïs Rat, Fernando Rodrigo Rosas Bringas, Pascale Jolivet, Rachel E. Langston, Stefano Mattarocci, Alexandre Maes, Théo Aspert, Bechara Zeinoun, Karine Casier, Hinke G. Kazemier, Gilles Charvin, Marie Doumic, Michael Chang, Maria Teresa Teixeira
The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.
Nature Communications · Mar 15, 2026Peer-reviewedMolecular Biology