Maria Teresa Teixeira

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

The paper identifies a new mitochondrial morphology in yeast called Ringo that enhances respiration by ensuring proper OXPHOS complex assembly.

This study develops a mathematical model to link telomere length and replicative senescence in yeast, revealing population dynamics and factors affecting proliferation capacity.

The paper shows Hog1 counteracts oxidative stress in telomerase-negative yeast during replicative senescence, independent of Mec1.

This study investigates how the Polo kinase Cdc5 is regulated during adaptation to telomere dysfunction in yeast, showing that its levels and phosphorylation status are critical for maintaining long-term cell cycle arrest.

The paper models non-terminal cell cycle arrests in telomerase-negative yeast to show they arise from a generation-dependent process distinct from terminal senescence.