Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells
Nicholas N. Jarjour, Talia S Dalzell, Nicholas Joseph Maurice, Kelsey Marie Wanhainen, Changwei Peng, Stephen D. O’Flanagan, Taylor A. DePauw, Katharine E. Block, William J. Valente, Katherine Maude Ashby, David Masopust, Stephen C. Jameson
This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.
Immunity · Feb 28, 2025Peer-reviewedImmunology