Author

Stephen D. O’Flanagan

University of MinnesotaORCID 0000-0002-9286-1208Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David MasopustiD· 2 shared Adam L. BurrackiD· 1 shared Alexander K. TsaiiD· 1 shared Ayaka Hulbert· 1 shared Changwei PengiD· 1 shared Eduardo Cruz-HinojozaiD· 1 shared Grant H. HickokiD· 1 shared Guhan QianiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

David MasopustORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma

Alexander K. Tsai, Meagan R. Rollins, Madeline A. Ellefson, Zoe C. Schmiechen, Adam L. Burrack, Ayaka Hulbert, Guhan Qian, Hongrong Zhang, Eduardo Cruz-Hinojoza, Jonah Z. Butler, Jason S. Mitchell, Olivia C. Ghirardelli Smith, Stephen D. O’Flanagan, Jenny Krause, Grant H. Hickok, , Ingunn M. Stromnes

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

Journal for ImmunoTherapy of Cancer · Oct 1, 2026Peer-reviewedImmunology

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells

Nicholas N. Jarjour, Talia S Dalzell, Nicholas Joseph Maurice, Kelsey Marie Wanhainen, Changwei Peng, Stephen D. O’Flanagan, Taylor A. DePauw, Katharine E. Block, William J. Valente, Katherine Maude Ashby, David Masopust, Stephen C. Jameson

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

Immunity · Feb 28, 2025Peer-reviewedImmunology