Author

William J. Valente

University of MinnesotaORCID 0000-0002-9330-944XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Organism:mouse· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Stephen C. JamesoniD· 2 shared Alexander K.C. WongiD· 1 shared Ameeta KelekariD· 1 shared Beau R. WebberiD· 1 shared Benjamin J. Hindson· 1 shared Branden S. MoriarityiD· 1 shared Changwei PengiD· 1 shared Christopher A. PennelliD· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Stephen C. JamesonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8+ T cells

Tingyuan Yang, Himani Sharma, Jenna M. Benson, William J. Valente, Rebecca S. LaRue, Beau R. Webber, Branden S. Moriarity, Christopher A. Pennell, Stephen C. Jameson, Ameeta Kelekar

This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.

bioRxiv · Dec 10, 2025 · PreprintImmunology

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells

Nicholas N. Jarjour, Talia S Dalzell, Nicholas Joseph Maurice, Kelsey Marie Wanhainen, Changwei Peng, Stephen D. O’Flanagan, Taylor A. DePauw, Katharine E. Block, William J. Valente, Katherine Maude Ashby, David Masopust, Stephen C. Jameson

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

Immunity · Feb 28, 2025Peer-reviewedImmunology

Massively parallel digital transcriptional profiling of single cells

Grace X. Y. Zheng, Jessica M. Terry, Phillip Belgrader, Paul Ryvkin, Zachary Bent, Ryan Wilson, Solongo B. Ziraldo, Tobias D. Wheeler, Geoff P. McDermott, Junjie Zhu, Mark Gregory, Joe Shuga, Luz Montesclaros, Jason G. Underwood, Don A. Masquelier, , Jason H. Bielas

8-channel GemCode droplet barcoding captures ∼50% of loaded cells for 3′ mRNA counting, profiling 68k peripheral blood mononuclear cells and calling transplant chimerism from transcript variants.

Nature Communications · Jan 16, 2017Peer-reviewedGenomics✦ In-depth digest