Yu Wang

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.

AB-Gen: Antibody Library Design with Generative Pre-trained Transformer and Deep Reinforcement Learning

AB-Gen uses reinforcement learning and a generative pre-trained Transformer to design antibody sequences with multiple desirable properties, improving success rates over traditional methods.

SmartGate is a spatial metabolomics tool for resolving tissue structures

SmartGate improves spatial segmentation and biomarker identification in IMS data through iterative peak picking and graph attention auto-encoder modeling.

Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

This paper identifies stable spatial gene expression patterns in the mouse brain using staNMF, revealing new regions and outperforming PCA and clustering methods.