Ka-Yiu Edwin Kong

The paper investigates how the SCFDas1 ubiquitin ligase recognizes C-terminal degrons, identifying a conserved binding site and key residues involved in substrate recognition.

This study identifies Gid11 as a substrate receptor for the GID ubiquitin ligase in budding yeast, revealing its role in regulating metabolic transitions by targeting glycolytic factors during ethanol metabolism.

The paper identifies over 5000 C-degrons in budding yeast and shows that the SCF ubiquitin ligase targets ~40% of them via the F-box receptor Das1.